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Kola nut, (cola nitida), is a caffeine-containing nut of two evergreen trees of the cocoa family (Sterculiaceae), native to tropical North Africa and cultivated extensively in the New World tropics. The nut has been used in medicines and in soft drinks, though American "colas" today instead use synthetic flavorings that mimic its taste. Kola nuts are also used where grown as a medium of exchange or are chewed to diminish sensations of hunger and fatigue, to aid digestion, and to combat intoxication, hangover, and diarrhea. If you are on medication where caffeine is contraindicated, you should not use Kola nut. Additionally, if you are pregnant or nursing, it is important to speak with your health care professional before using Kola nut.

Kola nut is not a supplement that should be taken without careful consideration as to its effects on the body. The FDA received more than 100 reports of injuries and adverse reactions related to a product containing Kola nut . There have been reported reactions ranging from serious, life-threatening conditions such as irregular heartbeat, heart attack, stroke, seizures, hepatitis and psychosis, to relatively minor and temporary conditions such as dizziness, headache, and gastrointestinal distress. FDA and outside medical experts have determined that the products represent a threat to health because Kola nut, can cause severe injury to people even under conditions of usual or recommended use. The FDA issued a warning to a product made by Alliance USA and the company reformulated the product by removing the Kola nut.